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  • Evidence is increasing that all addiction without exception is related to difficulty with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to shed pounds can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you need to err along the side of caution and let the FDA do its job and demand some study be done so the public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their medications.

    Researchers found that participants investing in this drug to get a year, dropped a few pounds within one month and have kept the load off during the entire 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs that are made up of several active ingredient, which may make them more efficient and safer.

    Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and therefore it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that as of right now there are not any long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure level and heartrate, and mustn't be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise hypertension and heart rate and must stop used in patients with uncontrolled high hypertension, and also by you aren't heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

    An independent report published by Gant Daily in April also stated that naltrexone also works well with kleptomaniacs and gambling addicts, also. Citing research through the University of Minnesota School of Medicine, Gant Daily reported that this drug works on kleptomaniacs and chronic gamblers just as with alcohol and opioid addicts'by blocking the end results of endorphins, that your brain releases when experiencing craving or compulsions.